-
Product Directory
Custom Product
-
Services Offered
Custom Capabilities
-
Sigma
Capsaicin
M2028 -
≥95%, from Capsicum sp.
DOWNLOAD MSDS (PDF)Synonym: 8-Methyl-N-vanillyl-trans-6-nonenamide
CAS Number: 404-86-4
Linear Formula: (CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)
Molecular Weight: 305.41
Beilstein Registry Number: 2816484
EC Number: 206-969-8
MDL number: MFCD00017259
PubChem Substance ID: 24896598
Properties
| Related Categories | Alkaloid, Bioactive Small Molecules, Biochemicals Found in Plants - sorted by compound type, Biochemicals Found in Plants - sorted by plant name, C-CH, |
| biological source | from Capsicum sp. |
| assay | ≥95% |
| mp | 62-65 °C(lit.) |
| solubility | H2O: insoluble |
| ethanol: soluble | |
| storage temp. | 2-8°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... CYP1A2(1544), TRPV1(7442) rat ... Trpv1(83810), Trpv4(66026) |
Description
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Other Notes
Active component of cayenne pepper
Biochem/physiol Actions
Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals.
Price and Availability
Customers Also Purchased
Documents
Certificate of Analysis
Certificate of Origin
| M2028 - Product Information Sheet (23 KB) |
| FT-IR Condensed Phase |  |
| FT-IR Raman | |
| FT-NMR |  |
| Transient Receptor Potential Channels (216 KB ) |
| Gene Information |
| Structure Search |  |
| Similar Products |
| Ask A Scientist |
Safety Information
| Symbol |    GHS05, GHS06, GHS08 |
| Signal word | Danger |
| Hazard statements | H301-H311-H315-H317-H318-H334-H335 |
| Precautionary statements | P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25-37/38-41-42/43 |
| Safety Statements | 22-26-28-36/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | RA8530000 |
| Flash Point(F) | 235.4 °F |
| Flash Point(C) | 113 °C |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
References
Ryu, V., et al., Plasticity Of Nodose Ganglion Neurons After Capsaicin- And Vagotomy-induced Nerve Damage In Adult Rats. Neuroscience 167, 1227-38, (2010) Abstract
Gallaher, Z.R., et al., Recovery Of Viscerosensory Innervation From The Dorsal Root Ganglia Of The Adult Rat Following Capsaicin-induced Injury. J. Comp. Neurol. 518, 3529-40, (2010) Abstract
Holzer, P., Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24, 739-768, (1988)
Bevan, S., and Szolcsanyi, J., Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci. 11, 330-333, (1990)
Merck 14,1768
Beil. 13,IV,2588
Arctander, 567 / FT-IR 2 (2), 2985:C / FT-NMR 1 (2), 1378:C / Fenaroli, 364 / RegBook 1 (2), 2009:M / Sax 6, 629 / Structure Index 1, 320:E:8
Printable Reviews
Share your experience with this product and how it worked in your specific application. We value your opinion and your colleagues will too!
Learn more at www.sigmaaldrich.com/reviews.
Technical Service:
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Bulk Ordering & Pricing:
Need larger quantities for your development, manufacturing or research applications?